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What is Glaucoma ?

Glaucoma is a disease that damages your eye’s optic nerve. It usually happens when fluid builds up in the front part of your eye. That extra fluid increases the pressure in your eye, damaging the optic nerve.
Glaucoma is second leading cause of blindness globally. When glaucoma develops, usually you don’t have any early symptoms and the disease progresses slowly. In this way, glaucoma can steal your sight very gradually. Fortunately, early detection and treatments can help preserve your vision. *1.2

Older people are at a higher risk for glaucoma but babies can be born with glaucoma, and young adults can get glaucoma, too. *3

In the healthy eye, a clear fluid called aqueous (pronounced AY-kwee-us) humor circulates inside the front portion of your eye. To maintain a constant healthy eye pressure, your eye continually produces a small amount of aqueous humor while an equal amount of this fluid flows out of your eye. If you have glaucoma, the aqueous humor does not flow out of the eye properly. Fluid pressure in the eye builds up and, over time, causes damage to the optic nerve fibers. *1.

Types of Glaucoma

There are several types of glaucoma.
The two main types are open-angle and angle-closure.

Open-Angle Glaucoma

Open-angle glaucoma is also called primary or chronic glaucoma. It is the most common type of glaucoma. In open angle glaucoma, the channels that drain fluid within the eye become blocked, causing the pressure within the eye to rise. It causes gradual loss of vision. There are few symptoms so that people may not notice for a long time that they are losing their sight.*1.2

Angle-closure glaucoma

Angle-closure glaucoma, a less common form of glaucoma. It is also called acute glaucoma or narrow-angle glaucoma. In angle closure glaucoma, there is a similar build up of fluid within the eye, but the onset is much more sudden. Symptoms include headaches, blurred vision and pain in the eye.*1.2

Other Types of Glaucoma

Normal-tension glaucoma
Congenital glaucoma
Secondary glaucoma
Neovascular Glaucoma

Glaucoma Treatment

ologenTM Collagen Matrix – Glaucoma



Mitomycin C (MMC) is teratogenic and associates with increased risks for conjunctiva thinning, bleb leakage, hypotony, blebitis, and endophthalmitis. ologenTM Collagen Matrix is an alternative to MMC that results in a non-scarring wound healing with a prominent filtering bleb to enable successful surgical outcome. The dangers of handling MMC are avoided. The surgery is made more time efficient by eliminating the need for the handling, application and disposal of MMC.

ologen™ Collagen Matrix has been demonstrated to be safe and biocompatible according to a series of biocompatibility requirements set forth under ISO 10993. ologen™ Collagen Matrix have been used in over 16,000 glaucoma filtering surgeries and other ophthalmic surgeries like pterygium excision, strabismus correction surgery, conjunctiva scar removal surgery. ologen™ Collagen Matrix is CE accredited and FDA 510(k) cleared for tissue repair and management of wound. It has been used in ocular surgery like glaucoma filtering surgery to induce non-scarring healing of ocular connective tissue without the need for MMC.

Episcleral fibrosis and subconjunctival scarring, the major causes of failure in filtering surgery, are formed as a result of migration and proliferation of fibroblasts followed by deposition of dense collagen bundles in the wound bed. ologen™ Collagen Matrix is a highly porous scaffolds that encourages random growth of fibroblasts through pores and secrete connective tissue in the form of a non-scarring loose matrix. ologen™ Collagen Matrix enables formation of bleb while maintains dynamic flow of aqueous humor.

Implantation of ologen™ Collagen Matrix is easily adapted without altering the standard trabeculectomy technique. The scleral flap is closed with a single to two loosely tied suture or releasable sutures. The surgeon then places ologen™ Collagen Matrix directly above the scleral flap before closing the conjunctiva. No suture is required to secure the ologen™ Collagen Matrix.

Occasional difficulty in lysing sutures with the laser through the implant has been encountered. The use of a single loosely tied suture or a releasable suture eliminates the challenge. Notwithstanding, it has been found that pressing firmly with a Blumenthal Laser Suture Lysis lens (Volk Optical, Inc. Mentor, OH) allows for visualization of most of the suture through the 12 x 1 mm2 ologen™ Collagen Matrix.

The hydraulic pressures of aqueous soaked collagen matrix provide resistance at the outlet of the scleral tunnel. The excessive outflow of aqueous humor is limited due to tamponading effect of ologen™ Collagen Matrix over the scleral flap. Over tight suture will severely impede out flow of aqueous humor, and leads to raised IOP.

  • Induce a regenerative non-scarring wound healing process without the use of anti-fibrotic agents
  • Act as aqueous reservoir creating a buffer to prevent flat or shallow anterior chamber
  • The surgical technique is easily adapted to suture scleral flap with a single loosely tied suture or a releasable suture
  • Enables formation of physiologic, functional bleb to avoid late complications of bleb leakage, blebitis, and endophthalmitis
  • Can be deployed readily without prior preparation
  • Surgery is made more time efficient by eliminating the need for handling, application and disposal of MMC
  • Not a teratogen like MMC.
  • Hydraulic pressure of aqueous soaked matrix provide resistance at the outlet of the scleral tunnel and to maintain the anterior chamber

ologen™ Collagen Matrix is an advanced wound care device designed for eye tissue repair mainly for glaucoma surgeries, for ohter applications, please contact us.

ologen Collagen Matrix is not available in all countries.

The product information of ologen Collagen Matrix shown on the website is provided according to CE approved instruction for use.